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2015 ; 10
(ä): 156
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NUT expression in primary lung tumours
#MMPMID26341600
Lund-Iversen M
; Grøholt KK
; Helland Å
; Borgen E
; Brustugun OT
Diagn Pathol
2015[Sep]; 10
(ä): 156
PMID26341600
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BACKGROUND: Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare,
highly aggressive epithelial neoplasms, characterised by protein expression of
NUT-fusion proteins which reflects the genetic translocation between chromosome
15 and 19. NMC occurs mainly in midline structures, but there are reports
regarding occurrence in structures outside the midline. We investigated specimens
from 519 surgically resected lung carcinomas and carcinoid tumours for the
presence of NUT protein using immunohistochemistry. Normal testis and two
previously confirmed NMCs served as positive controls. FINDINGS: All 483
evaluable cases (278 adenocarcinomas, 140 squamous cell carcinomas, 30 large cell
carcinomas, 7 small cell carcinomas, 10 undifferentiated carcinomas and 18
carcinoids) were completely negative for expression of NUT protein. CONCLUSION:
NUT gene rearrangement does not seem to be relevant in primary pulmonary
carcinomas or carcinoid tumours of the lung.
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