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10.1002/path.4775

http://scihub22266oqcxt.onion/10.1002/path.4775

C5071153!5071153 !27477320
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      J+Pathol 2016 ; 240 (3 ): 282-290
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NTRK3 kinase fusions in Spitz tumours JO: J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27477320 #FOAvip Oncogenic fusions in TRK family receptor tyrosine kinases have been identified in several cancers and can serve as therapeutic targets. We identified ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions in Spitz tumours, and demonstrated that NTRK3 fusions constitutively activate the mitogen-activated protein kinase, phosphoinositide 3-kinase and phospholipase C?1 pathways in melanocytes. This signalling was inhibited by DS-6051a, a small-molecule inhibitor of NTRK1/2/3 and ROS1. NTRK3 fusions expand the range of oncogenic kinase fusions in melanocytic neoplasms and offer targets for a small subset of melanomas for which no targeted options currently exist. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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NTRK3 kinase fusions in Spitz tumours ????J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27477320 #FOAvip
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NTRK3 kinase fusions in Spitz tumours #MMPMID27477320
Yeh I ; Tee MK ; Botton T ; Shain AH ; Sparatta AJ ; Gagnon A ; Vemula SS ; Garrido MC ; Nakamaru K ; Isoyama T ; McCalmont TH ; LeBoit PE ; Bastian BC
J Pathol 2016[Nov]; 240 (3 ): 282-290 PMID27477320 show ga
Oncogenic fusions in TRK family receptor tyrosine kinases have been identified in several cancers and can serve as therapeutic targets. We identified ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions in Spitz tumours, and demonstrated that NTRK3 fusions constitutively activate the mitogen-activated protein kinase, phosphoinositide 3-kinase and phospholipase C?1 pathways in melanocytes. This signalling was inhibited by DS-6051a, a small-molecule inhibitor of NTRK1/2/3 and ROS1. NTRK3 fusions expand the range of oncogenic kinase fusions in melanocytic neoplasms and offer targets for a small subset of melanomas for which no targeted options currently exist. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
|Adolescent [MESH]
|Adult [MESH]
|Aged [MESH]
|Child [MESH]
|Child, Preschool [MESH]
|Comparative Genomic Hybridization [MESH]
|Discoidin Domain Receptor 2/*genetics/metabolism [MESH]
|ETS Translocation Variant 6 Protein [MESH]
|Female [MESH]
|Humans [MESH]
|Male [MESH]
|Melanoma/enzymology/genetics/pathology [MESH]
|Mitogen-Activated Protein Kinases/genetics/metabolism [MESH]
|Molecular Motor Proteins/*genetics/metabolism [MESH]
|Myosin Heavy Chains/*genetics/metabolism [MESH]
|Myosin Type V/*genetics/metabolism [MESH]
|Nevus, Epithelioid and Spindle Cell/*enzymology/genetics/pathology [MESH]
|Oncogene Fusion [MESH]
|Phosphatidylinositol 3-Kinases/genetics/metabolism [MESH]
|Proto-Oncogene Proteins c-ets/*genetics/metabolism [MESH]
|Repressor Proteins/*genetics/metabolism [MESH]
|Sequence Analysis, DNA [MESH]
|Sequence Analysis, RNA [MESH]NTRK3 kinase fusions in Spitz tumours (epmc).pdf

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