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NTD Diagnostics for Disease Elimination: A Review
#MMPMID32517108
Taylor EM
Diagnostics (Basel)
2020[Jun]; 10
(6
): ä PMID32517108
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Neglected Tropical Diseases (NTDs) marked out for disease elimination provide a
lens through which to explore the changing status of diagnosis in global health.
This paper reports on the findings of a scoping review, which set out to explore
the main debates around diagnosis for the elimination of NTDs, including the
multiple roles diagnostic technologies are being ascribed and the ideal
characteristics of tests. It also attempts to summarise the state of diagnosis
for three NTDs with elimination goals. The review places special emphasis on
point-of-care testing in acknowledgement of the remote and underserved areas
where NTDs proliferate. Early NTD campaigns were largely focused on attack phase
planning, whereby a similar set of interventions could be transplanted anywhere.
Now, with elimination goals in sight, strategies must be tailored to local
settings if they are to attain and sustain success. Diagnostic data helps with
local adaptation and is increasingly used for programmatic decision-making. The
review finds that elimination goals reframe whom diagnosis is for and the myriad
roles diagnostics can play. The exigencies of elimination also serve to highlight
deficiencies in the current diagnostic arsenal and development pipeline for many
NTDs. Moving forward, a guiding framework is needed to drive research and
stimulate investment in diagnosis to support NTD goals.
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