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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Autophagy
2014 ; 10
(4
): 699-701
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NOX4 regulates autophagy during energy deprivation
#MMPMID24492492
Sciarretta S
; Volpe M
; Sadoshima J
Autophagy
2014[Apr]; 10
(4
): 699-701
PMID24492492
show ga
NADPH oxidase is a cellular enzyme devoted to the production of reactive oxygen
species (ROS). NOX4 and NOX2 are the main isoforms of NADPH oxidase in the
cardiovascular system. In our recent study, we demonstrated that NOX4, but not
NOX2, is a critical mediator of the cardiomyocyte adaptive response to energy
stress. NOX4 activity and protein levels are increased in the endoplasmic
reticulum (ER) but not in mitochondria of cardiomyocytes during the early phase
of energy deprivation. NOX4-derived production of ROS in the ER is a critical
event that activates autophagy through stimulation of the
EIF2AK3/PERK-EIF2S1/eIF-2?-ATF4 pathway. NOX4-dependent autophagy is an important
mechanism to preserve cellular energy and limit cell death in energy-deprived
cardiomyocytes. Aside from elucidating a crucial physiological function of NOX4
during cellular energy stress, our study dissects a novel signaling mechanism
that regulates autophagy under this condition.
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