Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27207962
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27207962
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Am+Heart+Assoc
2016 ; 5
(5
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
#MMPMID27207962
Paramel Varghese G
; Folkersen L
; Strawbridge RJ
; Halvorsen B
; Yndestad A
; Ranheim T
; Krohg-Sørensen K
; Skjelland M
; Espevik T
; Aukrust P
; Lengquist M
; Hedin U
; Jansson JH
; Fransén K
; Hansson GK
; Eriksson P
; Sirsjö A
J Am Heart Assoc
2016[May]; 5
(5
): ä PMID27207962
show ga
BACKGROUND: The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an
interleukin (IL)-1? and IL-18 cytokine processing complex that is activated in
inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis
of atherosclerosis and myocardial infarction is not fully understood. METHODS AND
RESULTS: Atherosclerotic plaques were analyzed for transcripts of the NLRP3
inflammasome, and for IL-1? release. The Swedish First-ever myocardial Infarction
study in Ac-county (FIA) cohort consisting of DNA from 555 myocardial infarction
patients and 1016 healthy individuals was used to determine the frequency of 4
single nucleotide polymorphisms (SNPs) from the downstream regulatory region of
NLRP3. Expression of NLRP3, Apoptosis-associated speck-like protein containing a
CARD (ASC), caspase-1 (CASP1), IL1B, and IL18 mRNA was significantly increased in
atherosclerotic plaques compared to normal arteries. The expression of NLRP3 mRNA
was significantly higher in plaques of symptomatic patients when compared to
asymptomatic ones. CD68-positive macrophages were observed in the same areas of
atherosclerotic lesions as NLRP3 and ASC expression. Occasionally, expression of
NLRP3 and ASC was also present in smooth muscle cells. Cholesterol crystals and
ATP induced IL-1? release from lipopolysaccharide-primed human atherosclerotic
lesion plaques. The minor alleles of the variants rs4266924, rs6672995, and
rs10733113 were associated with NLRP3 mRNA levels in peripheral blood mononuclear
cells but not with the risk of myocardial infarction. CONCLUSIONS: Our results
indicate a possible role of the NLRP3 inflammasome and its genetic variants in
the pathogenesis of atherosclerosis.
free
free
free
