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10.1007/s12026-014-8544-x http://scihub22266oqcxt.onion/10.1007/s12026-014-8544-x C5106291!5106291 !24989828     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24989828 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24989828 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunol+Res 2014 ; 59 (1-3 ): 142-52 Nephropedia Template TP {{tp|p=24989828 |t=2014. NLR proteins and parasitic disease |pdf=|usr=}}{{24989828 }} gab.com Text NLR proteins and parasitic disease JO: Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=24989828 #FOAvip Parasitic diseases are a serious global health concern. Many of the most common and most severe parasitic diseases, including Chagas' disease, leishmaniasis, and schistosomiasis, are also classified as neglected tropical diseases and are comparatively less studied than infectious diseases prevalent in high income nations. The NLRs (nucleotide-binding domain leucine-rich-repeat-containing proteins) are cytosolic proteins known to be involved in pathogen detection and host response. The role of NLRs in the host response to parasitic infection is just beginning to be understood. The NLR proteins NOD1 and NOD2 have been shown to contribute to immune responses during Trypanosoma cruzi infection, Toxoplasma gondii infection, and murine cerebral malaria. The NLRP3 inflammasome is activated by T. cruzi and Leishmania amazonensis but also induces pathology during infection with schistosomes or malaria. Both the NLRP1 and NLRP3 inflammasomes respond to T. gondii infection. The NLRs may play crucial roles in human immune responses during parasitic infection, usually acting as innate immune sensors and driving the inflammatory response against invading parasites. However, this inflammatory response can either kill the invading parasite or be responsible for destructive pathology. Therefore, understanding the role of the NLR proteins will be critical to understanding the host defense against parasites as well as the fine balance between homeostasis and parasitic disease. Twit Text FOAVip NLR proteins and parasitic disease ????Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=24989828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24989828 #FOAvip English Wikipedia <ref>{{Cite pmid|24989828 }}</ref> NLR proteins and parasitic disease #MMPMID24989828 Clay GM ; Sutterwala FS ; Wilson ME Immunol Res 2014[Aug]; 59 (1-3 ): 142-52 PMID24989828 show ga Parasitic diseases are a serious global health concern. Many of the most common and most severe parasitic diseases, including Chagas' disease, leishmaniasis, and schistosomiasis, are also classified as neglected tropical diseases and are comparatively less studied than infectious diseases prevalent in high income nations. The NLRs (nucleotide-binding domain leucine-rich-repeat-containing proteins) are cytosolic proteins known to be involved in pathogen detection and host response. The role of NLRs in the host response to parasitic infection is just beginning to be understood. The NLR proteins NOD1 and NOD2 have been shown to contribute to immune responses during Trypanosoma cruzi infection, Toxoplasma gondii infection, and murine cerebral malaria. The NLRP3 inflammasome is activated by T. cruzi and Leishmania amazonensis but also induces pathology during infection with schistosomes or malaria. Both the NLRP1 and NLRP3 inflammasomes respond to T. gondii infection. The NLRs may play crucial roles in human immune responses during parasitic infection, usually acting as innate immune sensors and driving the inflammatory response against invading parasites. However, this inflammatory response can either kill the invading parasite or be responsible for destructive pathology. Therefore, understanding the role of the NLR proteins will be critical to understanding the host defense against parasites as well as the fine balance between homeostasis and parasitic disease. |Adaptor Proteins, Signal Transducing/*immunology [MESH] |Animals [MESH] |Apoptosis Regulatory Proteins/*immunology [MESH] |Carrier Proteins/*immunology [MESH] |Humans [MESH] |Inflammasomes/*immunology [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein [MESH] |NLR Proteins [MESH] |Nod1 Signaling Adaptor Protein/immunology [MESH] |Nod2 Signaling Adaptor Protein/immunology [MESH] |Portraits as Topic [MESH]NLR proteins and parasitic disease (epmc).pdf DeepDyve Pubget Overpricing