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2015 ; 7
(6
): 828-38
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NIR fluorescent small molecules for intraoperative imaging
#MMPMID25645081
Owens EA
; Lee S
; Choi J
; Henary M
; Choi HS
Wiley Interdiscip Rev Nanomed Nanobiotechnol
2015[Nov]; 7
(6
): 828-38
PMID25645081
show ga
Recent advances in bioimaging and nanomedicine have permitted the exploitation of
molecular optical imaging in image-guided surgery; however, the parameters
mediating optimum performance of contrast agents are not yet precisely
determined. To develop ideal contrast agents for image-guided surgery, we need to
consider the following criteria: (1) excitation and emission wavelengths in the
near-infrared (NIR) window, (2) optimized optical characteristics for high in
vivo performance, (3) overcoming or harnessing biodistribution and clearance, and
(4) reducing nonspecific uptake. The design considerations should be focused on
optimizing the optical and physicochemical property criteria. Biodistribution and
clearance should first be considered because they mediate the fate of a contrast
agent in the body such as how long after intravenous injection a contrast agent
reaches the peak signal-to-background ratio (SBR) and how long the signal lasts
(retention).
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