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10.1038/s41467-017-00612-6 http://scihub22266oqcxt.onion/10.1038/s41467-017-00612-6 C5593830!5593830 !28894104     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28894104 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 511 Nephropedia Template TP {{tp|p=28894104 |t=2017. NFATc1 controls the cytotoxicity of CD8(+) T cells |pdf=|usr=}}{{28894104 }} gab.com Text NFATc1 controls the cytotoxicity of CD8(+) T cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28894104 #FOAvip Cytotoxic T lymphocytes are effector CD8(+) T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of Nfatc1 (-/-) cytotoxic T lymphocytes showed a defective cytoskeleton organization and recruitment of cytosolic organelles to immunological synapses. These cells have reduced cytotoxicity against tumor cells, and mice with NFATc1-deficient T cells are defective in controlling Listeria infection. Transcriptome analysis shows diminished RNA levels of numerous genes in Nfatc1 (-/-) CD8(+) T cells, including Tbx21, Gzmb and genes encoding cytokines and chemokines, and genes controlling glycolysis. Nfatc1 (-/-) , but not Nfatc2 (-/-) CD8(+) T cells have an impaired metabolic switch to glycolysis, which can be restored by IL-2. Genome-wide ChIP-seq shows that NFATc1 binds many genes that control cytotoxic T lymphocyte activity. Together these data indicate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.NFAT nuclear translocation has been shown to be required for CD8(+) T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8(+) T cells required for optimal response to bacteria and tumor cells. Twit Text FOAVip NFATc1 controls the cytotoxicity of CD8(+) T cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28894104 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28894104 #FOAvip English Wikipedia <ref>{{Cite pmid|28894104 }}</ref> NFATc1 controls the cytotoxicity of CD8(+) T cells #MMPMID28894104 Klein-Hessling S ; Muhammad K ; Klein M ; Pusch T ; Rudolf R ; Flöter J ; Qureischi M ; Beilhack A ; Vaeth M ; Kummerow C ; Backes C ; Schoppmeyer R ; Hahn U ; Hoth M ; Bopp T ; Berberich-Siebelt F ; Patra A ; Avots A ; Müller N ; Schulze A ; Serfling E Nat Commun 2017[Sep]; 8 (1 ): 511 PMID28894104 show ga Cytotoxic T lymphocytes are effector CD8(+) T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of Nfatc1 (-/-) cytotoxic T lymphocytes showed a defective cytoskeleton organization and recruitment of cytosolic organelles to immunological synapses. These cells have reduced cytotoxicity against tumor cells, and mice with NFATc1-deficient T cells are defective in controlling Listeria infection. Transcriptome analysis shows diminished RNA levels of numerous genes in Nfatc1 (-/-) CD8(+) T cells, including Tbx21, Gzmb and genes encoding cytokines and chemokines, and genes controlling glycolysis. Nfatc1 (-/-) , but not Nfatc2 (-/-) CD8(+) T cells have an impaired metabolic switch to glycolysis, which can be restored by IL-2. Genome-wide ChIP-seq shows that NFATc1 binds many genes that control cytotoxic T lymphocyte activity. Together these data indicate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.NFAT nuclear translocation has been shown to be required for CD8(+) T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8(+) T cells required for optimal response to bacteria and tumor cells. |Animals [MESH] |CD8-Positive T-Lymphocytes/immunology/metabolism [MESH] |Cytokines/genetics [MESH] |Cytoskeleton/metabolism [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Glycolysis/genetics [MESH] |Granzymes/genetics [MESH] |Immunological Synapses/*immunology/metabolism [MESH] |Listeriosis/immunology [MESH] |Lymphocyte Activation/*genetics/immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |NFATC Transcription Factors/*genetics/immunology [MESH] |Organelles/metabolism [MESH] |T-Box Domain Proteins/genetics [MESH] |T-Lymphocytes, Cytotoxic/*immunology/metabolism [MESH]NFATc1 controls the cytotoxicity of CD8(+) T cells (epmc).pdf DeepDyve Pubget Overpricing