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10.1111/cei.12730 http://scihub22266oqcxt.onion/10.1111/cei.12730 C4750596!4750596 !26462606     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26462606 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26462606 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Exp+Immunol 2016 ; 183 (3 ): 469-79 Nephropedia Template TP {{tp|p=26462606 |t=2016. NET amyloidogenic backbone in human activated neutrophils |pdf=|usr=}}{{26462606 }} gab.com Text NET amyloidogenic backbone in human activated neutrophils JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26462606 #FOAvip Activated human neutrophils produce a fibrillar DNA network [neutrophil extracellular traps (NETs)] for entrapping and killing bacteria, fungi, protozoa and viruses. Our results suggest that the neutrophil extracellular traps show a resistant amyloidogenic backbone utilized for addressing reputed proteins and DNA against the non-self. The formation of amyloid fibrils in neutrophils is regulated by the imbalance of reactive oxygen species (ROS) in the cytoplasm. The intensity and source of the ROS signal is determinant for promoting stress-associated responses such as amyloidogenesis and closely related events: autophagy, exosome release, activation of the adrenocorticotrophin hormone/?-melanocyte-stimulating hormone (ACTH/?-MSH) loop and synthesis of specific cytokines. These interconnected responses in human activated neutrophils, that have been evaluated from a morphofunctional and quantitative viewpoint, represent primitive, but potent, innate defence mechanisms. In invertebrates, circulating phagocytic immune cells, when activated, show responses similar to those described previously for activated human neutrophils. Invertebrate cells within endoplasmic reticulum cisternae produce a fibrillar material which is then assembled into an amyloidogenic scaffold utilized to convey melanin close to the invader. These findings, in consideration to the critical role played by NET in the development of several pathologies, could explain the structural resistance of these scaffolds and could provide the basis for developing new diagnostic and therapeutic approaches in immunomediated diseases in which the innate branch of the immune system has a pivotal role. Twit Text FOAVip NET amyloidogenic backbone in human activated neutrophils ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26462606 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26462606 #FOAvip English Wikipedia <ref>{{Cite pmid|26462606 }}</ref> NET amyloidogenic backbone in human activated neutrophils #MMPMID26462606 Pulze L ; Bassani B ; Gini E ; D'Antona P ; Grimaldi A ; Luini A ; Marino F ; Noonan DM ; Tettamanti G ; Valvassori R ; de Eguileor M Clin Exp Immunol 2016[Mar]; 183 (3 ): 469-79 PMID26462606 show ga Activated human neutrophils produce a fibrillar DNA network [neutrophil extracellular traps (NETs)] for entrapping and killing bacteria, fungi, protozoa and viruses. Our results suggest that the neutrophil extracellular traps show a resistant amyloidogenic backbone utilized for addressing reputed proteins and DNA against the non-self. The formation of amyloid fibrils in neutrophils is regulated by the imbalance of reactive oxygen species (ROS) in the cytoplasm. The intensity and source of the ROS signal is determinant for promoting stress-associated responses such as amyloidogenesis and closely related events: autophagy, exosome release, activation of the adrenocorticotrophin hormone/?-melanocyte-stimulating hormone (ACTH/?-MSH) loop and synthesis of specific cytokines. These interconnected responses in human activated neutrophils, that have been evaluated from a morphofunctional and quantitative viewpoint, represent primitive, but potent, innate defence mechanisms. In invertebrates, circulating phagocytic immune cells, when activated, show responses similar to those described previously for activated human neutrophils. Invertebrate cells within endoplasmic reticulum cisternae produce a fibrillar material which is then assembled into an amyloidogenic scaffold utilized to convey melanin close to the invader. These findings, in consideration to the critical role played by NET in the development of several pathologies, could explain the structural resistance of these scaffolds and could provide the basis for developing new diagnostic and therapeutic approaches in immunomediated diseases in which the innate branch of the immune system has a pivotal role. |*Neutrophil Activation [MESH] |Adrenocorticotropic Hormone/physiology [MESH] |Amyloid/*metabolism [MESH] |Animals [MESH] |Autophagy [MESH] |Exosomes/physiology [MESH] |Extracellular Traps/*immunology/*physiology [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Neutrophils/*immunology/ultrastructure [MESH] |Reactive Oxygen Species [MESH]NET amyloidogenic backbone in human activated neutrophils (epmc).pdf DeepDyve Pubget Overpricing