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Myocardial telocytes: a specific new cellular entity
#MMPMID20604817
Kostin S
J Cell Mol Med
2010[Jul]; 14
(7
): 1917-21
PMID20604817
show ga
The existence of a new type of interstitial cells in the heart namely,
interstitial Cajal-like cells (ICLC), has been described for the first time by
Hinescu and Popescu in 2005. This study was then followed by an ascending trend
of publications regarding the morphology, phenotype and distribution of
myocardial ICLC in diverse species including human patients. Recently the new
term 'telocytes' has been proposed for cells formerly known as ICLC, and the term
'telopodes' has been proposed for the prolongations of these cells. The
identification of these cells is based on ultrastructural criteria. In addition,
telocyters/telyopodes can be identified by several complementary approaches
including methylene blue vital staining, silver impregnation and immunoreactivity
against CD117/c-kit, vimentin, etc. This point of view presents critical data
existing in literature, as well as own results, which unequivocally provide
compelling evidence that telocytes are a new distinct cellular entity of
myocardial interstitium. Several presumable functions of the myocardial telocytes
are discussed: (i) intercellular signalling, (ii) cardiac repair/remodelling and
(iii) stem cell nursing in cardiac renewal.
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