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2015 ; 13
(2
): 105-11
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Myeloid-derived suppressor cells in inflammatory bowel disease
#MMPMID25931994
Kim YJ
; Chang SY
; Ko HJ
Intest Res
2015[Apr]; 13
(2
): 105-11
PMID25931994
show ga
Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs),
include neutrophilic and monocytic myeloid cells, and are found in inflammatory
loci and secondary lymphoid organs in mice with intestinal inflammation,
inflammatory bowel disease (IBD) patients, and tumor tissues. However, the roles
of MDSCs in IBD are not yet well understood, and there are controversies
regarding their immunosuppressive functions in IBD. In addition, recent studies
have suggested that endoplasmic reticulum (ER) stress in intestinal epithelial
cells, especially in Paneth cells, is closely associated with the induction of
IBD. However, the ER stress in MDSCs accumulated in the inflamed tissues of IBD
patients is not yet fully understood. In the current review, we discuss the
presence of accumulated MDSCs in the intestines of IBD patients, and further
speculate on their physiological roles in the inflammatory condition with
interleukin 17-producing cells, including Th17 cells. In particular, we will
discuss the divergent functions of MDSCs in ER stressed intestinal environments,
including their pro-inflammatory or immunosuppressive roles, based on the
consideration of unfolded protein responses initiated in intestinal epithelial
cells by ER stress.