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Myelodysplastic Syndromes: Updates and Nuances
#MMPMID28189174
Dao KT
Med Clin North Am
2017[Mar]; 101
(2
): 333-350
PMID28189174
show ga
Myelodysplastic syndrome (MDS) is a heterogeneous, clonal stem cell disorder of
the blood and marrow typically diagnosed based on the presence of persistent
cytopenia(s), dysplastic cells, and genetic markers. Common issues that arise in
the clinical management include difficulty confirming MDS diagnosis, lack of a
standard approach with novel agents in MDS, and few prospective long-term,
randomized controlled MDS clinical studies to guide allogeneic blood and marrow
transplant. With the recent genetic characterization of MDS, certain aspects of
these issues will be better addressed by integrating genetic data into clinical
study design and clinical practice.
|Bone Marrow Cells/cytology
[MESH]
|Chromatin Assembly and Disassembly/genetics
[MESH]
free
free
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