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10.1155/2015/301627 http://scihub22266oqcxt.onion/10.1155/2015/301627 C4539432!4539432 !26345532     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26345532 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice |pdf=|usr=}}{{26345532 }} gab.com Text Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26345532 #FOAvip Chronic low-grade inflammation is an important factor in the pathogenesis of diabetic complication. Mycophenolate mofetil (MMF) has an anti-inflammatory effect, inhibiting lymphocyte proliferation. Previous studies showed attenuation of diabetic nephropathy with MMF, but the underlying mechanisms were unclear. This study aimed to identify the effect of MMF on diabetic nephropathy and investigate its action mechanisms in type 2 diabetic mice model. Eight-week-old db/db and control mice (db/m mice) received vehicle or MMF at a dose of 30?mg/kg/day for 12 weeks. MMF-treated diabetic mice showed decreased albuminuria, attenuated mesangial expansion, and profibrotic mRNA expressions despite the high glucose level. The number of infiltrated CD4(+) and CD8(+) T cells in the kidney was significantly decreased in MMF-treated db/db mice and it resulted in attenuating elevated intrarenal TNF-? and IL-17. The renal chemokines expression and macrophages infiltration were also attenuated by MMF treatment. The decreased expression of glomerular nephrin and WT1 was recovered with MMF treatment. MMF prevented the progression of diabetic nephropathy in db/db mice independent of glycemic control. These results suggest that the effects of MMF in diabetic nephropathy are mediated by CD4(+) T cell regulation and related cytokines. Twit Text FOAVip Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26345532 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26345532 #FOAvip English Wikipedia <ref>{{Cite pmid|26345532 }}</ref> Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice #MMPMID26345532 Seo JW ; Kim YG ; Lee SH ; Lee A ; Kim DJ ; Jeong KH ; Lee KH ; Hwang SJ ; Woo JS ; Lim SJ ; Kim W ; Moon JY Biomed Res Int 2015[]; 2015 (ä): 301627 PMID26345532 show ga Chronic low-grade inflammation is an important factor in the pathogenesis of diabetic complication. Mycophenolate mofetil (MMF) has an anti-inflammatory effect, inhibiting lymphocyte proliferation. Previous studies showed attenuation of diabetic nephropathy with MMF, but the underlying mechanisms were unclear. This study aimed to identify the effect of MMF on diabetic nephropathy and investigate its action mechanisms in type 2 diabetic mice model. Eight-week-old db/db and control mice (db/m mice) received vehicle or MMF at a dose of 30?mg/kg/day for 12 weeks. MMF-treated diabetic mice showed decreased albuminuria, attenuated mesangial expansion, and profibrotic mRNA expressions despite the high glucose level. The number of infiltrated CD4(+) and CD8(+) T cells in the kidney was significantly decreased in MMF-treated db/db mice and it resulted in attenuating elevated intrarenal TNF-? and IL-17. The renal chemokines expression and macrophages infiltration were also attenuated by MMF treatment. The decreased expression of glomerular nephrin and WT1 was recovered with MMF treatment. MMF prevented the progression of diabetic nephropathy in db/db mice independent of glycemic control. These results suggest that the effects of MMF in diabetic nephropathy are mediated by CD4(+) T cell regulation and related cytokines. |Albuminuria/drug therapy/metabolism/pathology [MESH] |Animals [MESH] |Anti-Inflammatory Agents/*pharmacology [MESH] |CD4-Positive T-Lymphocytes/metabolism/pathology [MESH] |CD8-Positive T-Lymphocytes/metabolism/pathology [MESH] |Diabetes Mellitus, Experimental/*drug therapy/metabolism/pathology [MESH] |Diabetic Nephropathies/*drug therapy/metabolism/pathology [MESH] |Interleukin-17/metabolism [MESH] |Mice [MESH] |Mycophenolic Acid/*analogs & derivatives/pharmacology [MESH]Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice (epmc).pdf DeepDyve Pubget Overpricing