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10.1083/jcb.201603040 http://scihub22266oqcxt.onion/10.1083/jcb.201603040 C5350509!5350509 !28242744     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28242744 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2017 ; 216 (3 ): 583-594 Nephropedia Template TP {{tp|p=28242744 |t=2017. Mycobacterium tuberculosis replicates within necrotic human macrophages |pdf=|usr=}}{{28242744 }} gab.com Text Mycobacterium tuberculosis replicates within necrotic human macrophages JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28242744 #FOAvip Mycobacterium tuberculosis modulation of macrophage cell death is a well-documented phenomenon, but its role during bacterial replication is less characterized. In this study, we investigate the impact of plasma membrane (PM) integrity on bacterial replication in different functional populations of human primary macrophages. We discovered that IFN-? enhanced bacterial replication in macrophage colony-stimulating factor-differentiated macrophages more than in granulocyte-macrophage colony-stimulating factor-differentiated macrophages. We show that permissiveness in the different populations of macrophages to bacterial growth is the result of a differential ability to preserve PM integrity. By combining live-cell imaging, correlative light electron microscopy, and single-cell analysis, we found that after infection, a population of macrophages became necrotic, providing a niche for M. tuberculosis replication before escaping into the extracellular milieu. Thus, in addition to bacterial dissemination, necrotic cells provide first a niche for bacterial replication. Our results are relevant to understanding the environment of M. tuberculosis replication in the host. Twit Text FOAVip Mycobacterium tuberculosis replicates within necrotic human macrophages ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28242744 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28242744 #FOAvip English Wikipedia <ref>{{Cite pmid|28242744 }}</ref> Mycobacterium tuberculosis replicates within necrotic human macrophages #MMPMID28242744 Lerner TR ; Borel S ; Greenwood DJ ; Repnik U ; Russell MR ; Herbst S ; Jones ML ; Collinson LM ; Griffiths G ; Gutierrez MG J Cell Biol 2017[Mar]; 216 (3 ): 583-594 PMID28242744 show ga Mycobacterium tuberculosis modulation of macrophage cell death is a well-documented phenomenon, but its role during bacterial replication is less characterized. In this study, we investigate the impact of plasma membrane (PM) integrity on bacterial replication in different functional populations of human primary macrophages. We discovered that IFN-? enhanced bacterial replication in macrophage colony-stimulating factor-differentiated macrophages more than in granulocyte-macrophage colony-stimulating factor-differentiated macrophages. We show that permissiveness in the different populations of macrophages to bacterial growth is the result of a differential ability to preserve PM integrity. By combining live-cell imaging, correlative light electron microscopy, and single-cell analysis, we found that after infection, a population of macrophages became necrotic, providing a niche for M. tuberculosis replication before escaping into the extracellular milieu. Thus, in addition to bacterial dissemination, necrotic cells provide first a niche for bacterial replication. Our results are relevant to understanding the environment of M. tuberculosis replication in the host. |Cell Death/genetics [MESH] |Cell Differentiation/genetics [MESH] |Cells, Cultured [MESH] |DNA Replication/*genetics [MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/genetics [MESH] |Humans [MESH] |Interferon-gamma/genetics [MESH] |Leukocytes, Mononuclear/microbiology [MESH] |Macrophage Colony-Stimulating Factor/genetics [MESH] |Macrophages/*microbiology [MESH] |Mycobacterium tuberculosis/*genetics [MESH] |Necrosis/*genetics [MESH]Mycobacterium tuberculosis replicates within necrotic human macrophage(epmc).pdf DeepDyve Pubget Overpricing