Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28754702
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Mycobacterium abscessus Displays Fitness for Fomite Transmission
#MMPMID28754702
Malcolm KC
; Caceres SM
; Honda JR
; Davidson RM
; Epperson LE
; Strong M
; Chan ED
; Nick JA
Appl Environ Microbiol
2017[Oct]; 83
(19
): ? PMID28754702
show ga
Mycobacterium abscessus is a rapidly growing nontuberculous mycobacterium (NTM)
increasingly reported in soft tissue infections and chronic lung diseases,
including cystic fibrosis. The environmental source of M. abscessus has not been
definitively identified, but NTM have been detected in soil and water. To
determine the potential of soil-derived M. abscessus as an infectious source, we
explored the association, growth, and survival of M. abscessus with defined
mineral particulates, including kaolin, halloysite, and silicone dioxide, and
house dust as possible M. abscessus fomites. M. abscessus physically associated
with particulates, and the growth of M. abscessus was enhanced in the presence of
both kaolin and house dust. M. abscessus survived desiccation for 2 weeks but was
not viable after 3 weeks. The rate of decline of M. abscessus viability during
desiccation was reduced in the presence of house dust. The evidence for enhanced
growth and survival of M. abscessus during alternating growth and drying periods
suggests that dissemination could occur when in wet or dry environments. These
studies are important to understand environmental survival and acquisition of
NTM.IMPORTANCE The environmental source of pulmonary Mycobacterium abscessus
infections is not known. Fomites are nonliving carriers of infectious agents and
may contribute to acquisition of M. abscessus This study provides evidence that
M. abscessus growth is enhanced in the presence of particulates, using kaolin, an
abundant natural clay mineral, and house dust as experimental fomites. Moreover,
M. abscessus survived desiccation for up to 2 weeks in the presence of house
dust, kaolin, and several chemically defined mineral particulates; mycobacterial
viability during extended periods of dessication was enhanced by the presence of
house dust. The growth characteristics of M. abscessus with particulates suggest
that a fomite mechanism of transmission may contribute to M. abscessus
acquisition, which may lead to strategies to better control infections by M.
abscessus and related organisms.
free
free
free
