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2013 ; 4
(12
): 904-10
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gab.com Text
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Mutual regulation between Hippo signaling and actin cytoskeleton
#MMPMID24248471
Matsui Y
; Lai ZC
Protein Cell
2013[Dec]; 4
(12
): 904-10
PMID24248471
show ga
Hippo signaling plays a crucial role in growth control and tumor suppression by
regulating cell proliferation, apoptosis, and differentiation. How Hippo
signaling is regulated has been under extensive investigation. Over the past
three years, an increasing amount of data have supported a model of actin
cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a
downstream effector, Yki/Yap/Taz. On the other hand, Hippo signaling negatively
regulates actin cytoskeleton organization. This review provides insight on the
mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a
tight control of cell behaviors during animal development, and points out
outstanding questions for further investigations.
|Actin Cytoskeleton/*physiology
[MESH]
|Adaptor Proteins, Signal Transducing/genetics/metabolism
[MESH]
|Animals
[MESH]
|Cell Proliferation
[MESH]
|Drosophila Proteins/genetics/metabolism
[MESH]
|Gene Expression Regulation
[MESH]
|Hippo Signaling Pathway
[MESH]
|Humans
[MESH]
|Intracellular Signaling Peptides and Proteins/genetics/metabolism
[MESH]