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10.1038/bcj.2015.89 http://scihub22266oqcxt.onion/10.1038/bcj.2015.89 C4635197!4635197 !26473533     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26473533 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26473533 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood+Cancer+J 2015 ; 5 (10 ): e361 Nephropedia Template TP {{tp|p=26473533 |t=2015. Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas |pdf=|usr=}}{{26473533 }} gab.com Text Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas JO: Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=26473533 #FOAvip Subtypes of non-Hodgkin's lymphomas align with different stages of B-cell development. Germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and Burkitt's lymphoma (BL) each share molecular similarities with normal GCB cells. Recent next-generation sequencing studies have gained insight into the genetic etiology of these malignancies and revealed a high frequency of mutations within genes encoding proteins that modifying chromatin. These include activating and inactivating mutations of genes that perform post-translational modification of histones and organize chromatin structure. Here, we discuss the function of histone acetyltransferases (CREBBP, EP300), histone methyltransferases (KDM2C/D, EZH2) and regulators of higher order chromatin structure (HIST1H1C/D/E, ARID1A and SMARCA4) that have been reported to be mutated in ?5% of DLBCL, FL or BL. Mutations of these genes are an emerging hallmark of lymphomas with GCB-cell origins, and likely represent the next generation of therapeutic targets for these malignancies. Twit Text FOAVip Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas ????Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=26473533 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26473533 #FOAvip English Wikipedia <ref>{{Cite pmid|26473533 }}</ref> Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas #MMPMID26473533 Lunning MA ; Green MR Blood Cancer J 2015[Oct]; 5 (10 ): e361 PMID26473533 show ga Subtypes of non-Hodgkin's lymphomas align with different stages of B-cell development. Germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and Burkitt's lymphoma (BL) each share molecular similarities with normal GCB cells. Recent next-generation sequencing studies have gained insight into the genetic etiology of these malignancies and revealed a high frequency of mutations within genes encoding proteins that modifying chromatin. These include activating and inactivating mutations of genes that perform post-translational modification of histones and organize chromatin structure. Here, we discuss the function of histone acetyltransferases (CREBBP, EP300), histone methyltransferases (KDM2C/D, EZH2) and regulators of higher order chromatin structure (HIST1H1C/D/E, ARID1A and SMARCA4) that have been reported to be mutated in ?5% of DLBCL, FL or BL. Mutations of these genes are an emerging hallmark of lymphomas with GCB-cell origins, and likely represent the next generation of therapeutic targets for these malignancies. |*Mutation [MESH] |Animals [MESH] |Chromatin [MESH] |Germinal Center/pathology [MESH] |Histone Acetyltransferases/*genetics [MESH] |Histone Methyltransferases [MESH] |Histone-Lysine N-Methyltransferase/*genetics [MESH] |Humans [MESH] |Lymphoma, Large B-Cell, Diffuse/*genetics [MESH]Mutation of chromatin modifiers; an emerging hallmark of germinal cent(epmc).pdf DeepDyve Pubget Overpricing