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10.1016/j.coi.2016.12.002 http://scihub22266oqcxt.onion/10.1016/j.coi.2016.12.002 C5449224!5449224!28160624     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28160624.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Immunol 2017 ; 45 (ä): 31-6 Nephropedia Template TP {{tp|p=28160624|t=2017. Murine models of germinal center derived-lymphomas |pdf=|usr=}}{{28160624}} gab.com Text Murine models of germinal center derived-lymphomas JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28160624 #FOAvip The germinal center (GC) reaction is an adaptive immune response to select B cells bearing high-affinity B cell receptors (BCRs) to undergo further differentiation into antibody-producing cells or memory B cells. To drive affinity maturation, (GC) B cells undergo rounds of hypermutation and rapid proliferation, which can enhance susceptibility to malignant transformation. Lymphomas frequently originate from GC B cells, but the etiology for most lymphoma subtypes is unknown. Work in the past decade has more fully documented the mutational landscape in lymphomas, but the impact of these genomic lesions is often difficult to ascertain. In addition, while mutations affecting BCR signaling are well studied, the impact of extrinsic microenvironmental factors has not been widely addressed. Murine models are useful tools to study lymphomagenesis and disease progression, as well as potential treatment in a pre-clinical setting. Herein we discuss advances in murine models of lymphoma and how they inform on key characteristics of human lymphomas. Twit Text FOAVip Murine models of germinal center derived-lymphomas ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28160624 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28160624 #FOAvip English Wikipedia <ref>{{Cite pmid|28160624}}</ref> Murine models of germinal center derived-lymphomas #MMPMID28160624 Ramezani-Rad P; Rickert RC Curr Opin Immunol 2017[Apr]; 45 (ä): 31-6 PMID28160624show ga The germinal center (GC) reaction is an adaptive immune response to select B cells bearing high-affinity B cell receptors (BCRs) to undergo further differentiation into antibody-producing cells or memory B cells. To drive affinity maturation, (GC) B cells undergo rounds of hypermutation and rapid proliferation, which can enhance susceptibility to malignant transformation. Lymphomas frequently originate from GC B cells, but the etiology for most lymphoma subtypes is unknown. Work in the past decade has more fully documented the mutational landscape in lymphomas, but the impact of these genomic lesions is often difficult to ascertain. In addition, while mutations affecting BCR signaling are well studied, the impact of extrinsic microenvironmental factors has not been widely addressed. Murine models are useful tools to study lymphomagenesis and disease progression, as well as potential treatment in a pre-clinical setting. Herein we discuss advances in murine models of lymphoma and how they inform on key characteristics of human lymphomas. äMurine models of germinal center derived-lymphomas (epmc).pdf DeepDyve Pubget Overpricing