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Murine models of germinal center derived-lymphomas
#MMPMID28160624
Ramezani-Rad P
; Rickert RC
Curr Opin Immunol
2017[Apr]; 45
(?): 31-36
PMID28160624
show ga
The germinal center (GC) reaction is an adaptive immune response to select B
cells bearing high-affinity B cell receptors (BCRs) to undergo further
differentiation into antibody-producing cells or memory B cells. To drive
affinity maturation, (GC) B cells undergo rounds of hypermutation and rapid
proliferation, which can enhance susceptibility to malignant transformation.
Lymphomas frequently originate from GC B cells, but the etiology for most
lymphoma subtypes is unknown. Work in the past decade has more fully documented
the mutational landscape in lymphomas, but the impact of these genomic lesions is
often difficult to ascertain. In addition, while mutations affecting BCR
signaling are well studied, the impact of extrinsic microenvironmental factors
has not been widely addressed. Murine models are useful tools to study
lymphomagenesis and disease progression, as well as potential treatment in a
pre-clinical setting. Herein we discuss advances in murine models of lymphoma and
how they inform on key characteristics of human lymphomas.
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