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10.1021/acsnano.7b07060 http://scihub22266oqcxt.onion/10.1021/acsnano.7b07060 C5898240!5898240 !29286635     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29286635 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29286635 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Nano 2018 ; 12 (1 ): 494-503 Nephropedia Template TP {{tp|p=29286635 |t=2018. Multiplexed Profiling of Single Extracellular Vesicles |pdf=|usr=}}{{29286635 }} gab.com Text Multiplexed Profiling of Single Extracellular Vesicles JO: ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=29286635 #FOAvip Extracellular vesicles (EV) are a family of cell-originating, membrane-enveloped nanoparticles with diverse biological function, diagnostic potential, and therapeutic applications. While EV can be abundant in circulation, their small size (?4 order of magnitude smaller than cells) has necessitated bulk analyses, making many more nuanced biological explorations, cell of origin questions, or heterogeneity investigations impossible. Here we describe a single EV analysis (SEA) technique which is simple, sensitive, multiplexable, and practical. We profiled glioblastoma EV and discovered surprising variations in putative pan-EV as well as tumor cell markers on EV. These analyses shed light on the heterogeneous biomarker profiles of EV. The SEA technology has the potential to address fundamental questions in vesicle biology and clinical applications. Twit Text FOAVip Multiplexed Profiling of Single Extracellular Vesicles ????ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=29286635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29286635 #FOAvip English Wikipedia <ref>{{Cite pmid|29286635 }}</ref> Multiplexed Profiling of Single Extracellular Vesicles #MMPMID29286635 Lee K ; Fraser K ; Ghaddar B ; Yang K ; Kim E ; Balaj L ; Chiocca EA ; Breakefield XO ; Lee H ; Weissleder R ACS Nano 2018[Jan]; 12 (1 ): 494-503 PMID29286635 show ga Extracellular vesicles (EV) are a family of cell-originating, membrane-enveloped nanoparticles with diverse biological function, diagnostic potential, and therapeutic applications. While EV can be abundant in circulation, their small size (?4 order of magnitude smaller than cells) has necessitated bulk analyses, making many more nuanced biological explorations, cell of origin questions, or heterogeneity investigations impossible. Here we describe a single EV analysis (SEA) technique which is simple, sensitive, multiplexable, and practical. We profiled glioblastoma EV and discovered surprising variations in putative pan-EV as well as tumor cell markers on EV. These analyses shed light on the heterogeneous biomarker profiles of EV. The SEA technology has the potential to address fundamental questions in vesicle biology and clinical applications. |Biomarkers, Tumor/analysis [MESH] |Cell Line, Tumor [MESH] |Equipment Design [MESH] |Extracellular Vesicles/chemistry/*pathology [MESH] |Glioblastoma/chemistry/diagnostic imaging/*pathology [MESH] |Humans [MESH] |Lab-On-A-Chip Devices [MESH]Multiplexed Profiling of Single Extracellular Vesicles (epmc).pdf DeepDyve Pubget Overpricing