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2016 ; 7
(1
): 13
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Multiple sclerosis and primary vascular dysregulation (Flammer syndrome)
#MMPMID27307797
Konieczka K
; Koch S
; Binggeli T
; Schoetzau A
; Kesselring J
EPMA J
2016[]; 7
(1
): 13
PMID27307797
show ga
BACKGROUND: Multiple sclerosis (MS) is an inflammatory demyelinating disease of
the CNS of still unknown aetiology. Flammer syndrome (FS) encompasses a set of
symptoms and signs that are primarily but not solely related to the dysregulation
of blood vessels. The purpose of the present study was to determine whether FS
symptoms occur more often in MS patients than in controls. METHODS: Fifty-eight
MS patients and 259 controls answered a questionnaire covering 15 symptoms and
signs of FS. RESULTS: Six of the 15 symptoms and signs of FS (dizziness, low body
mass index, cold hands and/or feet, tendency toward perfectionism, reduced
thirst, feeling cold) were found significantly more often in MS patients than in
controls. Seven additional symptoms and signs (tinnitus, headaches, increased
pain sensation, long sleep-onset time, migraines, increased response to certain
drugs, low blood pressure) also occurred more often in MS patients, but the
difference in frequency was not statistically significant. One sign (reversible
skin blotches) was found less often in MS patients, but the difference in
frequency was not statistically significant. One symptom (increased smell
perception) was found significantly less often in MS patients. CONCLUSIONS: MS
patients suffer significantly more often from FS symptoms and signs than
controls. The reason for this association between MS and FS and the potential
implications of this association still need to be determined.