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2015 ; 42
(ä): 134-9
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Multiple roles of timing in somite formation
#MMPMID26116228
Stern CD
; Piatkowska AM
Semin Cell Dev Biol
2015[Jun]; 42
(ä): 134-9
PMID26116228
show ga
During development, vertebrate embryos produce serially repeated elements, the
somites, on each side of the midline. These generate the vertebral column,
skeletal musculature and dermis. They form sequentially, one pair at a time, from
mesenchymal tissue near the tail. Somite development is a complex process. The
embryo must control the number, size, and timing of somite formation, their
subdivision into functional regions along three axes, regional identity such that
somites develop in a region-specific way, and interactions with neighbouring
tissues that coordinate them with nearby structures. Here we discuss many
timing-related mechanisms that contribute to set up the spatial pattern.