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10.1038/srep10546 http://scihub22266oqcxt.onion/10.1038/srep10546 C4444958!4444958 !26014289     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26014289 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 10546 Nephropedia Template TP {{tp|p=26014289 |t=2015. Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics |pdf=|usr=}}{{26014289 }} gab.com Text Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26014289 #FOAvip Atomically layered transition metal dichalcogenides (TMDCs) exhibit a significant potential to enable next-generation low-cost transistor biosensors that permit single-molecule-level quantification of biomolecules. To realize such potential biosensing capability, device-oriented research is needed for calibrating the sensor responses to enable the quantification of the affinities/kinetics of biomolecule interactions. In this work, we demonstrated MoS2-based transistor biosensors capable of detecting tumor necrosis factor--alpha (TNF-?) with a detection limit as low as 60 fM. Such a detection limit was achieved in both linear and subthreshold regimes of MoS2 transistors. In both regimes, all sets of transistors exhibited consistent calibrated responses with respect to TNF-? concentration, and they resulted in a standard curve, from which the equilibrium constant of the antibody-(TNF-?) pair was extracted to be KD = 369 ± 48 fM. Based on this calibrated sensor model, the time-dependent binding kinetics was also measured and the association/dissociation rates of the antibody-(TNF-?) pair were extracted to be (5.03 ± 0.16) × 10(8) M(-1) s(-1) and (1.97 ± 0.08) × 10(-4) s(-1), respectively. This work advanced the critical device physics for leveraging the excellent electronic/structural properties of TMDCs in biosensing applications as well as the research capability in analyzing the biomolecule interactions with fM-level sensitivities. Twit Text FOAVip Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26014289 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26014289 #FOAvip English Wikipedia <ref>{{Cite pmid|26014289 }}</ref> Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics #MMPMID26014289 Nam H ; Oh BR ; Chen P ; Chen M ; Wi S ; Wan W ; Kurabayashi K ; Liang X Sci Rep 2015[May]; 5 (ä): 10546 PMID26014289 show ga Atomically layered transition metal dichalcogenides (TMDCs) exhibit a significant potential to enable next-generation low-cost transistor biosensors that permit single-molecule-level quantification of biomolecules. To realize such potential biosensing capability, device-oriented research is needed for calibrating the sensor responses to enable the quantification of the affinities/kinetics of biomolecule interactions. In this work, we demonstrated MoS2-based transistor biosensors capable of detecting tumor necrosis factor--alpha (TNF-?) with a detection limit as low as 60 fM. Such a detection limit was achieved in both linear and subthreshold regimes of MoS2 transistors. In both regimes, all sets of transistors exhibited consistent calibrated responses with respect to TNF-? concentration, and they resulted in a standard curve, from which the equilibrium constant of the antibody-(TNF-?) pair was extracted to be KD = 369 ± 48 fM. Based on this calibrated sensor model, the time-dependent binding kinetics was also measured and the association/dissociation rates of the antibody-(TNF-?) pair were extracted to be (5.03 ± 0.16) × 10(8) M(-1) s(-1) and (1.97 ± 0.08) × 10(-4) s(-1), respectively. This work advanced the critical device physics for leveraging the excellent electronic/structural properties of TMDCs in biosensing applications as well as the research capability in analyzing the biomolecule interactions with fM-level sensitivities. |*Transistors, Electronic [MESH] |Antibodies/immunology [MESH] |Biosensing Techniques/instrumentation/*methods [MESH] |Disulfides/*chemistry [MESH] |Equipment Design [MESH] |Kinetics [MESH] |Limit of Detection [MESH] |Molybdenum/*chemistry [MESH]Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics (epmc).pdf DeepDyve Pubget Overpricing