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2015 ; 2015
(ä): 493985
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Multiphysics and Multiscale Analysis for Chemotherapeutic Drug
#MMPMID26491672
Zhang L
; Kim SY
; Kim D
Biomed Res Int
2015[]; 2015
(ä): 493985
PMID26491672
show ga
This paper presents a three-dimensional dynamic model for the chemotherapy design
based on a multiphysics and multiscale approach. The model incorporates cancer
cells, matrix degrading enzymes (MDEs) secreted by cancer cells, degrading
extracellular matrix (ECM), and chemotherapeutic drug. Multiple mechanisms
related to each component possible in chemotherapy are systematically integrated
for high reliability of computational analysis of chemotherapy. Moreover, the
fidelity of the estimated efficacy of chemotherapy is enhanced by atomic
information associated with the diffusion characteristics of chemotherapeutic
drug, which is obtained from atomic simulations. With the developed model, the
invasion process of cancer cells in chemotherapy treatment is quantitatively
investigated. The performed simulations suggest a substantial potential of the
presented model for a reliable design technology of chemotherapy treatment.