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10.1093/nar/gkx637 http://scihub22266oqcxt.onion/10.1093/nar/gkx637 C5587800!5587800 !28911118     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28911118 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28911118 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2017 ; 45 (15 ): 8684-8696 Nephropedia Template TP {{tp|p=28911118 |t=2017. Multimerization rules for G-quadruplexes |pdf=|usr=}}{{28911118 }} gab.com Text Multimerization rules for G-quadruplexes JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28911118 #FOAvip G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures. Although most of these 256 variants existed primarily as monomers under the conditions of our screen, ?10% formed dimers or tetramers. These structures could form in a wide range of monovalent and divalent metal ions, and folding was highly cooperative in both KCl and MgCl2. As was previously shown for G-quadruplexes that bind GTP and promote peroxidase reactions, G-quadruplexes that form dimers and tetramers have distinct sequence requirements. Some mutants could also form heteromultimers, and a second screen was performed to characterize the sequence requirements of these structures. Taken together, these experiments provide new insights into the sequence requirements and structures of both homomultimeric and heteromultimeric G-quadruplexes. Twit Text FOAVip Multimerization rules for G-quadruplexes ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28911118 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28911118 #FOAvip English Wikipedia <ref>{{Cite pmid|28911118 }}</ref> Multimerization rules for G-quadruplexes #MMPMID28911118 Kolesnikova S ; Hubálek M ; Bednárová L ; Cvacka J ; Curtis EA Nucleic Acids Res 2017[Sep]; 45 (15 ): 8684-8696 PMID28911118 show ga G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures. Although most of these 256 variants existed primarily as monomers under the conditions of our screen, ?10% formed dimers or tetramers. These structures could form in a wide range of monovalent and divalent metal ions, and folding was highly cooperative in both KCl and MgCl2. As was previously shown for G-quadruplexes that bind GTP and promote peroxidase reactions, G-quadruplexes that form dimers and tetramers have distinct sequence requirements. Some mutants could also form heteromultimers, and a second screen was performed to characterize the sequence requirements of these structures. Taken together, these experiments provide new insights into the sequence requirements and structures of both homomultimeric and heteromultimeric G-quadruplexes. |*G-Quadruplexes [MESH] |Base Sequence [MESH] |Cations, Divalent/chemistry/pharmacology [MESH] |Circular Dichroism [MESH] |DNA/*chemistry [MESH] |Mutation/physiology [MESH] |Nucleic Acid Conformation [MESH]Multimerization rules for G-quadruplexes (epmc).pdf DeepDyve Pubget Overpricing