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2016 ; 7
(ä): 11566
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Multifunctional hydrogel nano-probes for atomic force microscopy
#MMPMID27199165
Lee JS
; Song J
; Kim SO
; Kim S
; Lee W
; Jackman JA
; Kim D
; Cho NJ
; Lee J
Nat Commun
2016[May]; 7
(ä): 11566
PMID27199165
show ga
Since the invention of the atomic force microscope (AFM) three decades ago, there
have been numerous advances in its measurement capabilities. Curiously,
throughout these developments, the fundamental nature of the force-sensing
probe-the key actuating element-has remained largely unchanged. It is produced by
long-established microfabrication etching strategies and typically composed of
silicon-based materials. Here, we report a new class of photopolymerizable
hydrogel nano-probes that are produced by bottom-up fabrication with compressible
replica moulding. The hydrogel probes demonstrate excellent capabilities for AFM
imaging and force measurement applications while enabling programmable,
multifunctional capabilities based on compositionally adjustable mechanical
properties and facile encapsulation of various nanomaterials. Taken together, the
simple, fast and affordable manufacturing route and multifunctional capabilities
of hydrogel AFM nano-probes highlight the potential of soft matter mechanical
transducers in nanotechnology applications. The fabrication scheme can also be
readily utilized to prepare hydrogel cantilevers, including in parallel arrays,
for nanomechanical sensor devices.