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10.1126/science.aad3292 http://scihub22266oqcxt.onion/10.1126/science.aad3292 C5496981!5496981 !26722002     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26722002 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2016 ; 351 (6268 ): aad3292 Nephropedia Template TP {{tp|p=26722002 |t=2016. Multidrug evolutionary strategies to reverse antibiotic resistance |pdf=|usr=}}{{26722002 }} gab.com Text Multidrug evolutionary strategies to reverse antibiotic resistance JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26722002 #FOAvip Antibiotic treatment has two conflicting effects: the desired, immediate effect of inhibiting bacterial growth and the undesired, long-term effect of promoting the evolution of resistance. Although these contrasting outcomes seem inextricably linked, recent work has revealed several ways by which antibiotics can be combined to inhibit bacterial growth while, counterintuitively, selecting against resistant mutants. Decoupling treatment efficacy from the risk of resistance can be achieved by exploiting specific interactions between drugs, and the ways in which resistance mutations to a given drug can modulate these interactions or increase the sensitivity of the bacteria to other compounds. Although their practical application requires much further development and validation, and relies on advances in genomic diagnostics, these discoveries suggest novel paradigms that may restrict or even reverse the evolution of resistance. Twit Text FOAVip Multidrug evolutionary strategies to reverse antibiotic resistance ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26722002 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26722002 #FOAvip English Wikipedia <ref>{{Cite pmid|26722002 }}</ref> Multidrug evolutionary strategies to reverse antibiotic resistance #MMPMID26722002 Baym M ; Stone LK ; Kishony R Science 2016[Jan]; 351 (6268 ): aad3292 PMID26722002 show ga Antibiotic treatment has two conflicting effects: the desired, immediate effect of inhibiting bacterial growth and the undesired, long-term effect of promoting the evolution of resistance. Although these contrasting outcomes seem inextricably linked, recent work has revealed several ways by which antibiotics can be combined to inhibit bacterial growth while, counterintuitively, selecting against resistant mutants. Decoupling treatment efficacy from the risk of resistance can be achieved by exploiting specific interactions between drugs, and the ways in which resistance mutations to a given drug can modulate these interactions or increase the sensitivity of the bacteria to other compounds. Although their practical application requires much further development and validation, and relies on advances in genomic diagnostics, these discoveries suggest novel paradigms that may restrict or even reverse the evolution of resistance. |*Evolution, Molecular [MESH] |Anti-Bacterial Agents/*pharmacology [MESH] |Bacteria/*drug effects/*genetics [MESH] |Drug Resistance, Bacterial/*genetics [MESH] |Humans [MESH] |Mutation [MESH]Multidrug evolutionary strategies to reverse antibiotic resistance (epmc).pdf DeepDyve Pubget Overpricing