Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nchembio.2224 http://scihub22266oqcxt.onion/10.1038/nchembio.2224 C5531067!5531067 !27820801     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27820801 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27820801 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Chem+Biol 2017 ; 13 (1 ): 9-11 Nephropedia Template TP {{tp|p=27820801 |t=2017. Multidimensional chemical control of CRISPR-Cas9 |pdf=|usr=}}{{27820801 }} gab.com Text Multidimensional chemical control of CRISPR-Cas9 JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=27820801 #FOAvip Cas9-based technologies have transformed genome engineering and the interrogation of genomic functions, but methods to control such technologies across numerous dimensions-including dose, time, specificity, and mutually exclusive modulation of multiple genes-are still lacking. We conferred such multidimensional controls to diverse Cas9 systems by leveraging small-molecule-regulated protein degron domains. Application of our strategy to both Cas9-mediated genome editing and transcriptional activities opens new avenues for systematic genome interrogation. Twit Text FOAVip Multidimensional chemical control of CRISPR-Cas9 ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=27820801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27820801 #FOAvip English Wikipedia <ref>{{Cite pmid|27820801 }}</ref> Multidimensional chemical control of CRISPR-Cas9 #MMPMID27820801 Maji B ; Moore CL ; Zetsche B ; Volz SE ; Zhang F ; Shoulders MD ; Choudhary A Nat Chem Biol 2017[Jan]; 13 (1 ): 9-11 PMID27820801 show ga Cas9-based technologies have transformed genome engineering and the interrogation of genomic functions, but methods to control such technologies across numerous dimensions-including dose, time, specificity, and mutually exclusive modulation of multiple genes-are still lacking. We conferred such multidimensional controls to diverse Cas9 systems by leveraging small-molecule-regulated protein degron domains. Application of our strategy to both Cas9-mediated genome editing and transcriptional activities opens new avenues for systematic genome interrogation. |CRISPR-Cas Systems/*genetics [MESH] |Cells, Cultured [MESH] |Gene Editing/*methods [MESH] |HEK293 Cells [MESH] |Humans [MESH] |INDEL Mutation/genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Transcription Factors/*genetics/*metabolism [MESH]Multidimensional chemical control of CRISPR-Cas9 (epmc).pdf DeepDyve Pubget Overpricing