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2018 ; 9
(8
): 2042-2064
Nephropedia Template TP
Chem Sci
2018[Feb]; 9
(8
): 2042-2064
PMID29732114
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Historically, the use of mechanochemical methods in synthesis has been almost
negligible, but their perception by the synthetic community has changed in recent
years and they are on their way to becoming mainstream. However, the
hybridization of mechanochemical synthesis with methodologies designed to
increase synthetic efficiency by allowing the generation of several bonds in a
single operation has taken off only recently, but it already constitutes a very
promising approach to sustainable chemistry. In this context, we provide in this
Perspective a critical summary and discussion of the main known synthetic methods
based on mechanochemical multicomponent reactions.
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