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2016 ; 2016
(ä): 1737-1746
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Multi-Trajectory Models of Chronic Kidney Disease Progression
#MMPMID28269932
Burckhardt P
; Nagin DS
; Padman R
AMIA Annu Symp Proc
2016[]; 2016
(ä): 1737-1746
PMID28269932
show ga
An ever increasing number of people are affected by chronic kidney disease (CKD).
A better understanding of the progression ofCKD and its complications is needed
to address what is becoming a major burden for health-care systems worldwide.
Utilizing a rich data set consisting of the Electronic Health Records (EHRs) of
more than 33,000 patients from a leading community nephrology practice in Western
Pennsylvania, we applied group-based trajectory modeling (GBTM) in order to
detect patient risk groups and uncover typical progressions of CKD and related
comorbidities and complications. We have found distinct risk groups with
differing trajectories and are able to classify new patients into these groups
with high accuracy (up to ? 90%). Our results suggest that multitrajectory
modeling via GBTM can shed light on the developmental course ofCKD and the
interactions between related complications.