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2015 ; 2015
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Moxonidine for tramadol withdrawal symptoms during detoxification
#MMPMID26156837
Talih F
; Ghossoub E
BMJ Case Rep
2015[Jul]; 2015
(ä): ä PMID26156837
show ga
It is well documented in the literature that noradrenergic pathways are key in
the manifestation of opioid withdrawal symptoms, which is why clonidine is used
as an off-label agent in opioid detoxification regimens given its
anti-sympathetic properties. Moxonidine is a selective I1-imidazoline receptor
agonist, similar to clonidine but with no ?2-adrenergic agonist activity and
subsequently fewer side effects. We report the case of a 33-year-old woman with a
15-year history of tramadol use who was admitted voluntarily for detoxification.
She was started on moxonidine and had an uneventful detoxification. Two months
after discharge, the patient maintained tramadol abstinence with good
tolerability to moxonidine. To the best of our knowledge, this has not been
previously reported in the medical literature.
|Adult
[MESH]
|Analgesics, Opioid/*adverse effects
[MESH]
|Antihypertensive Agents/pharmacology/*therapeutic use
[MESH]