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10.1172/JCI80819 http://scihub22266oqcxt.onion/10.1172/JCI80819 C4362263!4362263 !25689251     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25689251 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25689251 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2015 ; 125 (3 ): 975-7 Nephropedia Template TP {{tp|p=25689251 |t=2015. Moving upstream in the war on WNTs |pdf=|usr=}}{{25689251 }} gab.com Text Moving upstream in the war on WNTs JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25689251 #FOAvip Cholangiocarcinoma is a relatively rare cancer of the biliary ducts that is highly refractory to treatment. The factors that drive cholangiocarcinoma are poorly understood, though chronic liver fluke infection is a risk factor for disease. In this issue of the JCI, Boulter and colleagues demonstrate that the WNT/?-catenin signaling pathway is upregulated in patients with sporadic cholangiocarcinoma. The authors determined that macrophages generate WNT ligands in cholangiocarcinomas and depletion or inhibition of this cell population in animal models of cholangiocarcinoma reduced tumor burden and proliferation. Moreover, pharmacological inhibition of WNT secretion or ?-catenin activity was efficacious in animal models. Together the results of this study suggest that targeting WNT has potential as a therapeutic strategy for cholangiocarcinoma. Twit Text FOAVip Moving upstream in the war on WNTs ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25689251 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25689251 #FOAvip English Wikipedia <ref>{{Cite pmid|25689251 }}</ref> Moving upstream in the war on WNTs #MMPMID25689251 Virshup DM J Clin Invest 2015[Mar]; 125 (3 ): 975-7 PMID25689251 show ga Cholangiocarcinoma is a relatively rare cancer of the biliary ducts that is highly refractory to treatment. The factors that drive cholangiocarcinoma are poorly understood, though chronic liver fluke infection is a risk factor for disease. In this issue of the JCI, Boulter and colleagues demonstrate that the WNT/?-catenin signaling pathway is upregulated in patients with sporadic cholangiocarcinoma. The authors determined that macrophages generate WNT ligands in cholangiocarcinomas and depletion or inhibition of this cell population in animal models of cholangiocarcinoma reduced tumor burden and proliferation. Moreover, pharmacological inhibition of WNT secretion or ?-catenin activity was efficacious in animal models. Together the results of this study suggest that targeting WNT has potential as a therapeutic strategy for cholangiocarcinoma. |*Wnt Signaling Pathway [MESH] |Animals [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Benzeneacetamides/*pharmacology [MESH] |Bile Duct Neoplasms/*metabolism [MESH] |Bile Ducts, Intrahepatic/*metabolism [MESH] |Bridged Bicyclo Compounds, Heterocyclic/*pharmacology [MESH] |Cholangiocarcinoma/*metabolism [MESH] |Humans [MESH] |Male [MESH] |Pyridines/*pharmacology [MESH]Moving upstream in the war on WNTs (epmc).pdf DeepDyve Pubget Overpricing