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2015 ; 26
(9-10
): 379-90
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English Wikipedia
Mouse genome annotation by the RefSeq project
#MMPMID26215545
McGarvey KM
; Goldfarb T
; Cox E
; Farrell CM
; Gupta T
; Joardar VS
; Kodali VK
; Murphy MR
; O'Leary NA
; Pujar S
; Rajput B
; Rangwala SH
; Riddick LD
; Webb D
; Wright MW
; Murphy TD
; Pruitt KD
Mamm Genome
2015[Oct]; 26
(9-10
): 379-90
PMID26215545
show ga
Complete and accurate annotation of the mouse genome is critical to the
advancement of research conducted on this important model organism. The National
Center for Biotechnology Information (NCBI) develops and maintains many useful
resources to assist the mouse research community. In particular, the reference
sequence (RefSeq) database provides high-quality annotation of multiple mouse
genome assemblies using a combinatorial approach that leverages computation,
manual curation, and collaboration. Implementation of this conservative and
rigorous approach, which focuses on representation of only full-length and
non-redundant data, produces high-quality annotation products. RefSeq records
explicitly link sequences to current knowledge in a timely manner, updating
public records regularly and rapidly in response to nomenclature updates,
addition of new relevant publications, collaborator discussion, and user
feedback. Whole genome re-annotation is also conducted at least every 12-18
months, and often more frequently in response to assembly updates or availability
of informative data. This article highlights key features and advantages of
RefSeq genome annotation products and presents an overview of NCBI processes to
generate these data. Further discussion of NCBI's resources highlights useful
features and the best methods for accessing our data.
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