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2014 ; 3 Suppl 1
(Suppl 1
): S19-23
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English Wikipedia
Mother-to-Child Transmission of Herpes Simplex Virus
#MMPMID25232472
James SH
; Sheffield JS
; Kimberlin DW
J Pediatric Infect Dis Soc
2014[Sep]; 3 Suppl 1
(Suppl 1
): S19-23
PMID25232472
show ga
Infections with herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2), both alpha
herpesviruses, are highly prevalent worldwide. Both HSV types commonly cause
genital infection, which, when acquired or reactivated during pregnancy, carries
with it the risk of transmission to the fetus or neonate. Women who acquire
primary or first-episode genital herpes during pregnancy are at greater risk for
transmitting the infection than are women with recurrent genital herpes. Because
viral infection and reactivation are frequently asymptomatic, many affected women
are unaware of their infection and risk of transmission to their infants.
Neonatal HSV infection can have devastating long-term consequences, especially
when the central nervous system (CNS) is involved. Treatment of affected neonates
with intravenous acyclovir has improved outcomes but there is room for further
improvement, especially in regard to CNS disease. Working with pregnant women to
prevent mother-to-child transmission of HSV is an important component in reducing
the overall disease burden of neonatal HSV infections.