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2014 ; 20
(5
): 472-8
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Morbidity and mortality in sarcoidosis
#MMPMID25029298
Gerke AK
Curr Opin Pulm Med
2014[Sep]; 20
(5
): 472-8
PMID25029298
show ga
PURPOSE OF REVIEW: Chronic sarcoidosis is a complex disease with numerous
comorbid conditions and can be fatal in some cases. Recognizing causes of
morbidity and mortality is important to effectively select treatments, manage
symptoms and improve outcomes. The purpose of this review is to examine emerging
knowledge on morbidity and mortality in sarcoidosis. RECENT FINDINGS:
Approximately 1-5% of patients with sarcoidosis die from complications of
sarcoidosis. Recent population studies indicate that mortality may be increasing
over the past decade. The reasons behind these trends are unclear, but could
include increasing incidence, detection rates, severity of disease or age of the
population. Morbidity of sarcoidosis is reflected by a trend of increased
hospitalizations over recent years and increased use of healthcare resources.
Morbidity can be caused by organ damage from granulomatous inflammation,
treatment complications and psychosocial effects of the disease. Recent studies
are focused on morbidity related to cardiopulmonary complications, bone health
and ageing within the sarcoidosis population. Last, sarcoidosis is associated
with autoimmune diseases, pulmonary embolism and malignancy; however, the
underlying mechanisms linking diseases continue to be debated. SUMMARY: Morbidity
in sarcoidosis is significant and multifactorial. Mortality is infrequent, but
may be increasing over the years.
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