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2018 ; 7
(2
): ä Nephropedia Template TP
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English Wikipedia
Moonlighting with WDR5: A Cellular Multitasker
#MMPMID29385767
Guarnaccia AD
; Tansey WP
J Clin Med
2018[Jan]; 7
(2
): ä PMID29385767
show ga
WDR5 is a highly conserved WD40 repeat-containing protein that is essential for
proper regulation of multiple cellular processes. WDR5 is best characterized as a
core scaffolding component of histone methyltransferase complexes, but emerging
evidence demonstrates that it does much more, ranging from expanded functions in
the nucleus through to controlling the integrity of cell division. The purpose of
this review is to describe the current molecular understandings of WDR5, discuss
how it participates in diverse cellular processes, and highlight drug discovery
efforts around WDR5 that may form the basis of new anti-cancer therapies.