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2014 ; 74
(5
): 1287-93
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Monocyte subpopulations in angiogenesis
#MMPMID24556724
Dalton HJ
; Armaiz-Pena GN
; Gonzalez-Villasana V
; Lopez-Berestein G
; Bar-Eli M
; Sood AK
Cancer Res
2014[Mar]; 74
(5
): 1287-93
PMID24556724
show ga
Growing understanding of the role of the tumor microenvironment in angiogenesis
has brought monocyte-derived cells into focus. Monocyte subpopulations are an
increasingly attractive therapeutic target in many pathologic states, including
cancer. Before monocyte-directed therapies can be fully harnessed for clinical
use, understanding of monocyte-driven angiogenesis in tissue development and
homeostasis, as well as malignancy, is required. Here, we provide an overview of
the mechanisms by which monocytic subpopulations contribute to angiogenesis in
tissue and tumor development, highlight gaps in our existing knowledge, and
discuss opportunities to exploit these cells for clinical benefit.