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10.1016/j.urology.2016.03.004 http://scihub22266oqcxt.onion/10.1016/j.urology.2016.03.004 C4914421!4914421 !26972146     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26972146 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Urology 2016 ; 93 (ä): 224.e1-6 Nephropedia Template TP {{tp|p=26972146 |t=2016. Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers |pdf=|usr=}}{{26972146 }} gab.com Text Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers JO: Urology http://www.kidney.de/pget.php?&tw=1&pmid=26972146 #FOAvip OBJECTIVE: To investigate whether mitochondrial function is altered in circulating immune cells from calcium oxalate (CaOx) stone formers compared to healthy subjects. MATERIALS AND METHODS: Adult healthy subjects (n?=?18) and CaOx stone formers (n?=?12) were included in a pilot study. Data collection included demographic and clinical values from electronic medical records. Bioenergetic function was assessed in monocytes, lymphocytes, and platelets isolated from blood samples using the Seahorse XF96 Analyzer. Plasma interleukin-6 (IL-6) was measured using enzyme-linked immunosorbent assay. RESULTS: All participants were age matched (44.5?±?3.0 years for healthy subjects vs 42.3?±?4.8 years for CaOx stone formers, P?=?.6905). CaOx stone formers did not have urinary tract infection, ureteral stones, or obstructing renal stones. Monocyte mitochondrial function was decreased in CaOx stone formers compared to healthy subjects. Specifically, mitochondrial maximal respiration (P?=?.0011) and reserve capacity (P?<?.0001) were significantly lower. In contrast, lymphocyte and platelet mitochondrial function was similar between the 2 groups. The bioenergetic health index, an integrated value of mitochondrial function, was significantly lower in monocytes from CaOx stone formers compared to healthy subjects (P?=?.0041). Lastly, plasma IL-6 levels were significantly increased (P?=?.0324). CONCLUSION: The present pilot study shows that CaOx stone formers have decreased monocyte mitochondrial function. Plasma IL-6 was also increased in this cohort. These data suggest that impaired monocyte mitochondrial function and inflammation may be linked to CaOx kidney stone formation. Further studies are needed to confirm these findings in a larger cohort of patients. Twit Text FOAVip Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers ????Urology http://www.kidney.de/pget.php?&tw=1&pmid=26972146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26972146 #FOAvip English Wikipedia <ref>{{Cite pmid|26972146 }}</ref> Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers #MMPMID26972146 Williams J ; Holmes RP ; Assimos DG ; Mitchell T Urology 2016[Jul]; 93 (ä): 224.e1-6 PMID26972146 show ga OBJECTIVE: To investigate whether mitochondrial function is altered in circulating immune cells from calcium oxalate (CaOx) stone formers compared to healthy subjects. MATERIALS AND METHODS: Adult healthy subjects (n?=?18) and CaOx stone formers (n?=?12) were included in a pilot study. Data collection included demographic and clinical values from electronic medical records. Bioenergetic function was assessed in monocytes, lymphocytes, and platelets isolated from blood samples using the Seahorse XF96 Analyzer. Plasma interleukin-6 (IL-6) was measured using enzyme-linked immunosorbent assay. RESULTS: All participants were age matched (44.5?±?3.0 years for healthy subjects vs 42.3?±?4.8 years for CaOx stone formers, P?=?.6905). CaOx stone formers did not have urinary tract infection, ureteral stones, or obstructing renal stones. Monocyte mitochondrial function was decreased in CaOx stone formers compared to healthy subjects. Specifically, mitochondrial maximal respiration (P?=?.0011) and reserve capacity (P? |Adult [MESH] |Calcium Oxalate/analysis/*metabolism [MESH] |Female [MESH] |Humans [MESH] |Interleukin-6/blood [MESH] |Kidney Calculi/chemistry/*etiology/*metabolism [MESH] |Male [MESH] |Mitochondria/*physiology [MESH] |Monocytes/*physiology [MESH]Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers (epmc).pdf DeepDyve Pubget Overpricing