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2015 ; 83
(3
): 852-62
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Monkey models of tuberculosis: lessons learned
#MMPMID25547788
Peņa JC
; Ho WZ
Infect Immun
2015[Mar]; 83
(3
): 852-62
PMID25547788
show ga
The use of animal models has been invaluable for studying the pathogenesis of
Mycobacterium tuberculosis infection, as well as for testing the efficacy of
vaccines and drug regimens for tuberculosis. Among the applied animal models,
nonhuman primates, particularly macaques, share the greatest anatomical and
physiological similarities with humans. As such, macaque models have been used
for investigating tuberculosis pathogenesis and preclinical testing of drugs and
vaccines. This review focuses on published major studies which illustrate how the
rhesus and cynomolgus macaques have enriched and may continue to advance the
field of global tuberculosis research.
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