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Molecular pathophysiology of cerebral edema
#MMPMID26661240
Stokum JA
; Gerzanich V
; Simard JM
J Cereb Blood Flow Metab
2016[Mar]; 36
(3
): 513-38
PMID26661240
show ga
Advancements in molecular biology have led to a greater understanding of the
individual proteins responsible for generating cerebral edema. In large part, the
study of cerebral edema is the study of maladaptive ion transport. Following
acute CNS injury, cells of the neurovascular unit, particularly brain endothelial
cells and astrocytes, undergo a program of pre- and post-transcriptional changes
in the activity of ion channels and transporters. These changes can result in
maladaptive ion transport and the generation of abnormal osmotic forces that,
ultimately, manifest as cerebral edema. This review discusses past models and
current knowledge regarding the molecular and cellular pathophysiology of
cerebral edema.
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