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2017 ; 65
(8
): 764-767
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Molecular pathologic interpretation of new retinoblastoma rosettes
#MMPMID28820171
Das D
; Deka P
; Bhattacharjee K
; Barman MJ
; Bhattacharjee H
; Misra D
; Saxena RK
; Bhattacharyya A
; Deka A
Indian J Ophthalmol
2017[Aug]; 65
(8
): 764-767
PMID28820171
show ga
Newly described retinoblastoma (RB) rosettes have various kinds of pathological
significance. Some of their characteristics have been revealed in this
immunohistochemistry study. Five paraffin-embedded eyeballs with RB and new
rosettes were studied for neuron-specific enolase (NSE), p53, p16, BAX, c-Myc,
glial fibrillary acidic protein, synaptophysin, and chromogranin. They were
compared and interpreted using control specimens. NSE, P53, and P16 were
significantly expressed in the cells of the new rosettes. The presence of new RB
rosettes that mostly have histopathological high-risk factors and p53 positivity
may be a strong marker of poor prognosis of RB.