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2013 ; 5
(9
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Molecular mechanisms of the membrane sculpting ESCRT pathway
#MMPMID24003212
Henne WM
; Stenmark H
; Emr SD
Cold Spring Harb Perspect Biol
2013[Sep]; 5
(9
): ä PMID24003212
show ga
The endosomal sorting complexes required for transport (ESCRT) drive
multivesicular body (MVB) biogenesis and cytokinetic abscission. Originally
identified through genetics and cell biology, more recent work has begun to
elucidate the molecular mechanisms of ESCRT-mediated membrane remodeling, with
special focus on the ESCRT-III complex. In particular, several light and electron
microscopic studies provide high-resolution imaging of ESCRT-III rings and
spirals that purportedly drive MVB morphogenesis and abscission. These studies
highlight unifying principles to ESCRT-III function, in particular: (1) the
ordered assembly of the ESCRT-III monomers into a heteropolymer, (2) ESCRT-III as
a dynamic complex, and (3) the role of the AAA ATPase Vps4 as a contributing
factor in membrane scission. Mechanistic comparisons of ESCRT-III function in MVB
morphogenesis and cytokinesis suggest common mechanisms in membrane remodeling.
|*Models, Biological
[MESH]
|Cell Membrane/*physiology
[MESH]
|Cytokinesis/*physiology
[MESH]
|Endosomal Sorting Complexes Required for Transport/*biosynthesis/*metabolism
[MESH]