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2015 ; 116
(8
): 1477-90
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Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart
#MMPMID25858070
Saito T
; Sadoshima J
Circ Res
2015[Apr]; 116
(8
): 1477-90
PMID25858070
show ga
Mitochondrial quality is a crucial determinant of cell viability, and
mitochondrial autophagy plays a central role in this control mechanism. Based on
studies in yeast, numerous investigations of this process have been conducted,
and the framework of mammalian mitochondrial autophagy is progressively
appearing. However, many enigmas about the molecular mechanisms involved remain
unsolved. Furthermore, the pathological significance of mitochondrial autophagy
in the heart remains largely unclear. In this review, we discuss the current
understanding of mitochondrial autophagy in mammals with reference to that in
yeast. Regarding the process in yeast, some points of uncertainty have arisen. We
also summarize recent advances in the research of autophagy and mitochondrial
autophagy in the heart. This article is a part of a review series on Autophagy in
Health and Disease.
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