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Molecular mechanisms of hepatic apoptosis
#MMPMID24434519
Wang K
Cell Death Dis
2014[Jan]; 5
(1
): e996
PMID24434519
show ga
Apoptosis is a prominent feature of liver diseases. Causative factors such as
alcohol, viruses, toxic bile acids, fatty acids, drugs, and immune response, can
induce apoptotic cell death via membrane receptors and intracellular stress.
Apoptotic signaling network, including membrane death receptor-mediated cascade,
reactive oxygen species (ROS) generation, endoplasmic reticulum (ER) stress,
lysosomal permeabilization, and mitochondrial dysfunction, is intermixed each
other, but one mechanism may dominate at a particular stage. Mechanisms of
hepatic apoptosis are complicated by multiple signaling pathways. The progression
of liver disease is affected by the balance between apoptotic and antiapoptotic
capabilities. Therapeutic options of liver injury are impacted by the clear
understanding toward mechanisms of hepatic apoptosis.
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