Nat Neurosci
2015[Mar]; 18
(3
): 367-72
PMID25710839
show ga
Decades of experimental work have established an imbalance of excitation and
inhibition as the leading mechanism of the transition from normal brain function
to seizure. In epilepsy, these transitions are rare and abrupt. Transition
processes incorporating positive feedback, such as activity-dependent
disinhibition, could provide these uncommon timing features. A rapidly expanding
array of genetic etiologies will help delineate the molecular mechanism(s). This
delineation will entail quite a bit of cell biology. The genes discovered so far
are more remarkable for their diversity than their similarities.
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