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10.1146/annurev-biophys-083012-130404 http://scihub22266oqcxt.onion/10.1146/annurev-biophys-083012-130404 C5895182!5895182 !23654304     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23654304 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Biophys 2013 ; 42 (ä): 217-39 Nephropedia Template TP {{tp|p=23654304 |t=2013. Molecular mechanisms of RNA interference |pdf=|usr=}}{{23654304 }} gab.com Text Molecular mechanisms of RNA interference JO: Annu Rev Biophys http://www.kidney.de/pget.php?&tw=1&pmid=23654304 #FOAvip Small RNA molecules regulate eukaryotic gene expression during development and in response to stresses including viral infection. Specialized ribonucleases and RNA-binding proteins govern the production and action of small regulatory RNAs. After initial processing in the nucleus by Drosha, precursor microRNAs (pre-miRNAs) are transported to the cytoplasm, where Dicer cleavage generates mature microRNAs (miRNAs) and short interfering RNAs (siRNAs). These double-stranded products assemble with Argonaute proteins such that one strand is preferentially selected and used to guide sequence-specific silencing of complementary target mRNAs by endonucleolytic cleavage or translational repression. Molecular structures of Dicer and Argonaute proteins, and of RNA-bound complexes, have offered exciting insights into the mechanisms operating at the heart of RNA-silencing pathways. Twit Text FOAVip Molecular mechanisms of RNA interference ????Annu Rev Biophys http://www.kidney.de/pget.php?&tw=1&pmid=23654304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23654304 #FOAvip English Wikipedia <ref>{{Cite pmid|23654304 }}</ref> Molecular mechanisms of RNA interference #MMPMID23654304 Wilson RC ; Doudna JA Annu Rev Biophys 2013[]; 42 (ä): 217-39 PMID23654304 show ga Small RNA molecules regulate eukaryotic gene expression during development and in response to stresses including viral infection. Specialized ribonucleases and RNA-binding proteins govern the production and action of small regulatory RNAs. After initial processing in the nucleus by Drosha, precursor microRNAs (pre-miRNAs) are transported to the cytoplasm, where Dicer cleavage generates mature microRNAs (miRNAs) and short interfering RNAs (siRNAs). These double-stranded products assemble with Argonaute proteins such that one strand is preferentially selected and used to guide sequence-specific silencing of complementary target mRNAs by endonucleolytic cleavage or translational repression. Molecular structures of Dicer and Argonaute proteins, and of RNA-bound complexes, have offered exciting insights into the mechanisms operating at the heart of RNA-silencing pathways. |*Gene Expression Regulation [MESH] |*RNA Interference [MESH] |Animals [MESH] |Argonaute Proteins/chemistry/metabolism [MESH] |Cell Nucleus/genetics/metabolism [MESH] |Cytoplasm/genetics/metabolism [MESH] |Humans [MESH] |MicroRNAs/genetics/*metabolism [MESH] |RNA, Small Interfering/genetics/*metabolism [MESH]Molecular mechanisms of RNA interference (epmc).pdf DeepDyve Pubget Overpricing