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2014 ; 21
(6
): 1112-28; quiz 1129
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Molecular imaging of plaque vulnerability
#MMPMID25124827
Tavakoli S
; Vashist A
; Sadeghi MM
J Nucl Cardiol
2014[Dec]; 21
(6
): 1112-28; quiz 1129
PMID25124827
show ga
Over the past decade, significant progress has been made in the development of
novel imaging strategies focusing on the biology of the vessel wall for
identification of vulnerable plaques. While the majority of these studies are
still in the pre-clinical stage, few techniques (e.g., (18)F-FDG and (18)F-NaF
PET imaging) have already been evaluated in clinical studies with promising
results. Here, we will briefly review the pathobiology of atherosclerosis and
discuss molecular imaging strategies that have been developed to target these
events, with an emphasis on mechanisms that are associated with atherosclerotic
plaque vulnerability.