Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27119098
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Molecular imaging of oncolytic viral therapy
#MMPMID27119098
Haddad D
; Fong Y
Mol Ther Oncolytics
2015[]; 1
(?): 14007
PMID27119098
show ga
Oncolytic viruses have made their mark on the cancer world as a potential
therapeutic option, with the possible advantages of reduced side effects and
strengthened treatment efficacy due to higher tumor selectivity. Results have
been so promising, that oncolytic viral treatments have now been approved for
clinical trials in several countries. However, clinical studies may benefit from
the ability to noninvasively and serially identify sites of viral targeting via
molecular imaging in order to provide safety, efficacy, and toxicity information.
Furthermore, molecular imaging of oncolytic viral therapy may provide a more
sensitive and specific diagnostic technique to detect tumor origin and, more
importantly, presence of metastases. Several strategies have been investigated
for molecular imaging of viral replication broadly categorized into optical and
deep tissue imaging, utilizing several reporter genes encoding for fluorescence
proteins, conditional enzymes, and membrane protein and transporters. Various
imaging methods facilitate molecular imaging, including computer tomography,
magnetic resonance imaging, positron emission tomography, single photon emission
CT, gamma-scintigraphy, and photoacoustic imaging. In addition, several molecular
probes are used for medical imaging, which act as targeting moieties or signaling
agents. This review will explore the preclinical and clinical use of in vivo
molecular imaging of replication-competent oncolytic viral therapy.