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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Drug+Deliv+Rev
2014 ; 66
(ä): 90-100
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Molecular imaging for cancer diagnosis and surgery
#MMPMID24064465
Hussain T
; Nguyen QT
Adv Drug Deliv Rev
2014[Feb]; 66
(ä): 90-100
PMID24064465
show ga
Novel molecular imaging techniques have the potential to significantly enhance
the diagnostic and therapeutic approaches for cancer treatment. For solid tumors
in particular, novel molecular enhancers for imaging modalities such as US, CT,
MRI and PET may facilitate earlier and more accurate diagnosis and staging which
are prerequisites for successful surgical therapy. Enzymatically activatable
"smart" molecular MRI probes seem particularly promising because of their
potential to image tumors before and after surgical removal without
re-administration of the probe to evaluate completeness of surgical resection.
Furthermore, the use of "smart" MR probes as part of screening programs may
enable detection of small tumors throughout the body in at-risk patient
populations. Dual labeling of molecular MR probes with fluorescent dyes can add
real time intraoperative guidance facilitating complete tumor resection and
preservation of important structures. A truly theranostic approach with the
further addition of therapeutic agents to the molecular probe for adjuvant
therapy is conceivable for the future.