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2014 ; 1
(2
): e954507
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Molecular dynamics of PLK1 during mitosis
#MMPMID27308323
Schmucker S
; Sumara I
Mol Cell Oncol
2014[Apr]; 1
(2
): e954507
PMID27308323
show ga
Polo-like kinase 1 (PLK1) is a key regulator of eukaryotic cell division. During
mitosis, dynamic regulation of PLK1 is crucial for its roles in centrosome
maturation, spindle assembly, microtubule-kinetochore attachment, and
cytokinesis. Similar to other members of the PLK family, the molecular
architecture of PLK1 protein is characterized by 2 domains-the kinase domain and
the regulatory substrate-binding domain (polo-box domain)-that cooperate and
control PLK1 function during mitosis. Mitotic cells employ many layers of
regulation to activate and target PLK1 to different cellular structures in a
timely manner. During the last decade, numerous studies have shed light on the
precise molecular mechanisms orchestrating the mitotic activity of PLK1 in time
and space. This review aims to discuss available data and concepts related to
regulation of the molecular dynamics of human PLK1 during mitotic progression.