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10.1038/ni.3306 http://scihub22266oqcxt.onion/10.1038/ni.3306 C4795476!4795476 !26681459     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26681459 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2016 ; 17 (1 ): 26-33 Nephropedia Template TP {{tp|p=26681459 |t=2016. Molecular control of activation and priming in macrophages |pdf=|usr=}}{{26681459 }} gab.com Text Molecular control of activation and priming in macrophages JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26681459 #FOAvip In tissues, macrophages are exposed to metabolic, homeostatic and immunoregulatory signals of local or systemic origin that influence their basal functions and responses to danger signals. Signal-transduction pathways regulated by extracellular signals are coupled to distinct sets of broadly expressed stimulus-regulated transcription factors whose ability to elicit gene-expression changes is influenced by the accessibility of their binding sites in the macrophage genome. In turn, accessibility of macrophage-specific transcriptional regulatory elements (enhancers and promoters) is specified by transcription factors that determine the macrophage lineage or impose their tissue-specific properties. Here we review recent findings that advance the understanding of mechanisms underlying priming and signal-dependent activation of macrophages and discuss the effect of genetic variation on these processes. Twit Text FOAVip Molecular control of activation and priming in macrophages ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26681459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26681459 #FOAvip English Wikipedia <ref>{{Cite pmid|26681459 }}</ref> Molecular control of activation and priming in macrophages #MMPMID26681459 Glass CK ; Natoli G Nat Immunol 2016[Jan]; 17 (1 ): 26-33 PMID26681459 show ga In tissues, macrophages are exposed to metabolic, homeostatic and immunoregulatory signals of local or systemic origin that influence their basal functions and responses to danger signals. Signal-transduction pathways regulated by extracellular signals are coupled to distinct sets of broadly expressed stimulus-regulated transcription factors whose ability to elicit gene-expression changes is influenced by the accessibility of their binding sites in the macrophage genome. In turn, accessibility of macrophage-specific transcriptional regulatory elements (enhancers and promoters) is specified by transcription factors that determine the macrophage lineage or impose their tissue-specific properties. Here we review recent findings that advance the understanding of mechanisms underlying priming and signal-dependent activation of macrophages and discuss the effect of genetic variation on these processes. |*Macrophages/cytology/immunology [MESH] |Animals [MESH] |Epigenesis, Genetic/*immunology [MESH] |Gene Expression Regulation/immunology [MESH] |Humans [MESH] |Macrophage Activation/*immunology [MESH]Molecular control of activation and priming in macrophages (epmc).pdf DeepDyve Pubget Overpricing